Midway via his vocation, Cees Dekker reinvented himself. Soon after years of hardcore physics, he shifted his concentration to ‘nanobiology’ in the convert from the millennium. A expression he coined himself, as being a subject of reality.
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Again in 1991, Sumio Iijima of your NEC Company had described the synthesis of carbon nanotubes. Band framework calculations prompt that these nanotubes could show metallic band conduction. This would be a significant advantage more than the conducting polymers we had explored, which had been, actually, disordered semiconductors providing simply variable-variety hopping conductivity.
Considering the fact that 2000, Dekker has shifted the most crucial concentrate of his get the job done toward biophysics where he scientific tests the properties of single biomolecules and cells utilizing the tools of nanotechnology. This modification of area was pushed by his fascination for your impressive operating of biological molecular buildings, together with by the very long-term perspective that a lot of appealing discoveries is often predicted Within this area.[5] Current traces of research in his biophysics team are in the parts of:[6]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial ever review in the dynamics DNA supercoils and the invention of supercoil hopping
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
All parameters have been the exact same for every panel in this video, except for the Preliminary placement on the 6hb rod (demonstrated in blue) to the nanopore. Simulations that terminated early as a consequence of translocation of the rod with the pore are marked by a grey track record.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, in addition to a ceesdekker 3D rendering in the movement on the DNA rod is displayed.
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There was a single dilemma while — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of fantastic conductors, which was fairly disappointing. We Hence broadened our look at to try to discover far more promising molecules.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial mobile division
2006, to start with demonstration of molecular sorting inside a lab on the chip working with biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
2008, very first observation of protein-coated DNA translocation by means of nanopores; settled the origin from the electrophoretic force on DNA in nanopores; discovered a significant velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes