‘The next is nanopores, that's our oldest line of investigation and that has now resulted in DNA sequencers determined by nanopores. We pull specific DNA strands by way of a nanopore and may then read off the nucleotide sequence. Very lately, we even managed to study out only one protein for The 1st time applying This method. But this line of investigation is not merely about developing resources, but in addition about actual biological questions.
Human Rad51 filaments on double- and single-stranded DNA: correlating typical and irregular sorts with recombination purpose.
Multicolor imaging in the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the most crucial emphasis of his work in the direction of biophysics wherever he studies the Homes of solitary biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the outstanding working of Organic molecular buildings, and by the extended-phrase point of view that many fascinating discoveries can be expected On this field.[5] Recent traces of exploration in his biophysics team are during the parts of:[six]
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Experimental phase diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
MATLAB codes for knowledge processing are available at . Julia codes employed for numerical simulation can be found at .
2000, discovery that nanotubes can carry remarkable significant present densities; solved the controversial difficulty of electronic transport by DNA molecules by measurements of insulating behavior at the single molecule stage; and demonstration of the AFM technique for single-molecule manipulation of nanotubes
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‘The fantastically subtle way in which features in character operate by no means ceases to amaze me. If we solve the puzzle of how life arrived https://www.ceesdekker.net into currently being, I count on that my amazement in the complexity of generation will likely have improved and with it my awe for the greatness of your Creator.’
[14] In 2005 Dekker turned involved in Netherlands-extensive discussions about Smart Structure, a motion that he has because Evidently distanced himself from. Dekker advocates that science and religion will not be in opposition but can be harmonized.
Nature Physics many thanks the anonymous reviewers for his or her contribution for the peer assessment of the operate.
Such as, we think about the nucleopore advanced, a gateway amongst the cell nucleus as well as cytoplasm. This is an extremely difficult system and as a consequence tough to research inside of a mobile, so we use biomimetics. We reconstruct holes and after that insert unique things in the nucleopore complicated to check transport as a result of it at The only-molecule level.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design and style in 2005. (nl)